货号: | WL03214 |
抗体名: | P-P53(Ser 315) 抗体 |
抗体英文名: | P-P53(Ser 315) antibody |
浓度: | >1mg/ml |
应用范围: | WB |
宿主: | 兔 |
适应物种: | H,M,R |
标记物: | 无 |
克隆性: | 否 |
保存条件: | -20℃ |
形态: | 液体 |
亚型: | IgG |
规格: | 50μl(>50μg) |
本公司所有一抗,50μl(>50μg)现价450元/支,全部现货,均提供20μl免费试用装,详情请点击免费试用
产品货号 | WL03214 | |||
产品名称 | P-P53(Ser 315) Antibody | |||
预测分子量 | 53 kDa | |||
别名 | P-Tp53; P-BCC7; P-LFS1; P-TRP53 | |||
浓度 | >1 mg/ml | |||
免疫原 | 合成P-P53(Ser 315)多肽 | |||
抗体来源 | 兔 | |||
特异性 | 抗人、小鼠、大鼠 | |||
克隆类型 | 多克隆抗体 | |||
产品应用 | WB | |||
成分 | 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02% | |||
保存条件 | -20℃保存 | |||
背景资料 | p53, a DNA-binding, oligomerization domain- and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation, and cell cycle control mechanisms. In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor . Aurora A phosphorylates p53 at Ser315 in a cell cycle-dependent manner leading to MDM2-mediated ubiquitination/degradation of p53. | |||
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