货号: | WL0171 |
抗体名: | DR5 抗体 |
抗体英文名: | DR5 antibody |
浓度: | >1mg/ml |
应用范围: | WB,IHC |
宿主: | 兔 |
适应物种: | H,M,R |
标记物: | 无 |
克隆性: | 否 |
保存条件: | -20℃ |
形态: | 液体 |
亚型: | IgG |
规格: | 50μl(>50μg) |
产品货号 | WL0171 | |||
产品名称 | DR5 Antibody | |||
预测分子量 | 55kDa | |||
别名 | CD262; KILLER; TRAILR2; TRICK2; TRICKB; ZTNFR9 | |||
浓度 | >1 mg/ml | |||
免疫原 | 合成DR5多肽 | |||
抗体来源 | 兔 | |||
特异性 | 抗人、小鼠、大鼠 | |||
克隆类型 | 多克隆抗体 | |||
产品应用 | WB; IHC | |||
成分 | 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02% | |||
保存条件 | -20℃保存 | |||
背景资料 | DR5 is a receptor for TNF-related apoptosis inducing ligand (TRAIL), which has been been shown to induce apoptosis in variety of cell types and has been targeted for cancer therapy. Structurally, DR5 contains an amino-terminal leader cleavage site followed by an extracellular region containing two cysteine-rich repeats, then a central transmembrane domain and a carboxy-terminal death domain. DR5 is expressed in a wide variety of tissues and is transcriptional target for p53. It induces apoptosis through a FADD-dependent pathway. Deletion of DR5 leads to resistance in TRAIL-mediated apoptosis as well as an abrogated response to DNA-damaging stimuli. | |||
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