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明胶 （来源于冷水鱼皮肤）
EZ-VISION® ONE, DNA DYE AS LOADING
1-苯基-1，3-丁二酮
[VIP第1年] 指数:2
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Kolliphor® P 188
胶原蛋白酶 来源于溶
细胞爬片| 货号： | S1037 |
| 英文名： | AKT inhibitors |
| CAS号： | 157716-52-4 |
| 供应商： | 上海研卉生物 |
| 数量： | 大量 |
| 规格： | 5/10/50mg |
Perifosine 的生物活性
Perifosine，AKT 抑制剂，AKT inhibitors，CAS:157716-52-4Perifosine抑制Akt，抗肿瘤增生，IC50为0.6–8.9 µM。Perifosine抑制巴西利什曼原虫，亚马逊利什曼原虫，大利什曼原虫，小利什曼原虫，IC50分别为0.79±0.03, 3.62±0.36 , 0.19±0.27, 0.078±0.29μg/ml。 [2] 用替莫唑胺和perifosine处 理的肿瘤有最低的Ki-67染色指数(1.7 ± 1.2%)[1]。在头颈部鳞癌细胞中，Perifosine间接抑制cdc2, cdk2, and cdk4/6 活性。在细胞周期G1期和G2-M期，10uM Perifosine可以捕获头颈部鳞癌细胞。 [4] 结肠直肠癌由直肠、结肠及阑尾处的细胞不受控制的生长引起的。Perifosine用于治疗结肠直肠癌已经处在三期阶段。 [3] 最初是由Keryx Biopharmaceuticals研究的。
Perifosine 参考文献
[1] Hiroyuki Momota, et al. Cancer Res August 15, 2005 65; 7429
[2] María Gabriela Cabrera-Serra,et al. Parasitol Res (2007) 100:1155–1157
[3] http://en.wikipedia.org/wiki/Perifosine
[4] Vyomesh Patel,et al. Cancer Res 2002;62:1401-1409.
| 别名: | KRX-0401 |
|---|---|
| 分子量 (MW): | 461.66 |
| 化学式: | C25H52NO4P |
| 溶解度: | DMSO <1mg/mL Water ≥14mg/mL Ethanol ≥92mg/mL |
| 稳定性: | at -20℃ 2 years |
| CAS号: | 157716-52-4 |
Perifosine产品的论文
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Antitumoral Alkylphospholipids Induce Cholesterol Efflux from the Plasma Membrane in HepG2 Cells.
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Insulin-Like Growth Factor I Suppresses Bone Morphogenetic Protein Signaling in Prostate Cancer Cells by Activating mTOR Signaling.
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Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues.
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Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation.
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The Akt Inhibitor MK2206 Synergizes, but Perifosine Antagonizes, the BRAFV600E Inhibitor PLX4032 and the MEK1/2 Inhibitor AZD6244 in the Inhibition of Thyroid Cancer Cells.
温馨提示：不可用于临床治疗。
