货号: | WLp1512 |
抗体名: | p-ERK1/2 (Thr202/Tyr204) 抗体 |
抗体英文名: | p-ERK1/2 (Thr202/Tyr204) Antibody |
浓度: | >1mg/ml |
应用范围: | WB,IHC |
宿主: | 兔 |
适应物种: | H,M,R |
标记物: | 无 |
克隆性: | 否 |
保存条件: | -20℃ |
形态: | 液体 |
亚型: | IgG |
规格: | 50μl(>50μg) |
本公司所有一抗,50μl(>50μg)现价450元/支,全部现货,均提供20μl免费试用装,详情请点击免费试用 产品货号 | WLP1512 | 产品名称 | p-ERK1/2 (Thr202/Tyr204) Antibody | 预测分子量 | 42/44kDa | 别名 | P-ERK1;P- ERK2;P- ERT1;P- ERT2; P-MAPK1; P-MAPK2; P-MAPK3; P- P42mapk; P-P44erk1; P-PRKM1; P-PRKM2; P-PRKM3 | 浓度 | >1 mg/ml | 免疫原 | 合成p-ERK1/2 (Thr202+Tyr204) 多肽 | 抗体来源 | 兔 | 特异性 | 抗人,小鼠,大鼠 | 克隆类型 | 多克隆抗体 | 产品应用 | WB;IHC | 成分 | 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02% | 保存条件 | -20℃保存 | 背景资料 | Extracellular signal-regulated kinases Erk1 (p44 MAPK) and Erk2 (p42 MAPK) Serine/Threonine protein kinase are part of a subfamily of mitogen-activated protein kinases. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors and cytokines. Upon stimulation, a sequential three-part protein kinase cascade is initiated consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K) and a MAP kinase (MAPK). Phospho-ERK1/2 is negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs (10), along with MEK inhibitors such as U0126 and PD98059. | | | | | | | | | |
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