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Gendre固定液
HEPES(1M),货号:15630080
(R)-2-羟基-3-甲基丁酸甲酯
[VIP第1年] 指数:1
通过认证 
E7080
Papaverine hydrochlo
骨架化合物库；骨架库
Cabotegravir (GSK744
凋亡化合物库；细胞凋| 货号： | T4099 |
| 供应商： | TargetMol中国 |
| 数量： | 大量 |
| 英文名： | S-38093 |
| 保质期： | 干粉三年 |
| 保存条件： | -20°C |
| 规格： | 1mg/2mg/5mg/10mg/20mg/50mg/100mg/200mg/10mM * 1mL (in DMSO) |
美国进口，中国现货
溶解度Solubility：15mg/mL in DMSO
Pathways：GPCR/G Protein; Immunology/Inflammation; Neuroscience
Target：Histamine Receptor antagonist
Receptor：Human H3 receptor; Mouse H3 receptor; Rat H3 receptor
Bioactivity：S38093 is a brain-penetrant antagonist of H3 receptor, with Ki of 8.8, 1.44 and 1.2 µM for rat, mouse and human H3 receptors, respectively.
体外实验：In cellular models, S 38093 is able to antagonize mice H3 receptors (KB=0.65 µM) and to suppress cAMP decrease induced by an H3 agonist via human H3 receptors (KB=0.11 µM). In cells expressing a high H3 density, S 38093 behaves as a moderate inverse agonist at rat and human H3 receptors (EC50=9 and 1.7 µM, respectively)[2].
体内实验：S 38093 (0.3 and 3 mg/kg/d p.o., 28 days) significantly increases proliferation of progenitors in the DG of hippocampus in young adult mice. S 38093 (0.3 mg/kg/d) treatment significantly increases the number of DCX+ cells with tertiary dendrites. S 38093 (0.3, 1 and/or 3 mg/kg) significantly increases cell proliferation, survival, and maturation in the DG of hippocampus in aged mice relative to vehicle. S 38093 (3 mg/kg/d p.o., 28 days) increases cell proliferation and has a strong effect on cell survival, also increases the dendritic intersections in both genotypes (one-way ANOVA with repeated measure, p < 0.01), with a significant effect from 50 to 80 in APPSWETG mice only. In aged mice, chronic administration of S 38093 (1 and/or 3 mg/kg/day p.o., 28 days) reverses this age-dependent decrease in BDNF-IX, BDNF-IV and BDNF-I transcripts. In addition, S 38093 at three tested doses (0.3, 1 and 3 mg/kg/d) increases VEGF transcripts compared to vehicle-aged group[1]. In mice, S 38093 significantly increases ex vivo N-tele-Methylhistamine cerebral levels from 3 mg/kg p.o. and antagonized R-α-Methylhistamine-induced dipsogenia from 10 mg/kg i.p[2].
更多产品信息，请点击：http://www.tsbiochem.com/productview/s-38093.html
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经过在中国市场近十年的精心耕耘，我们已成为筛选化合物领域优秀的供应商，为超过五百家学校和各类企业提供了品质卓越的小分子化合物和药物筛选服务。相信未来，我们可以帮助更多的客户完成他们的科研梦想！
温馨提示：不可用于临床治疗。
