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MicroVue CICP EIA*| 货号： | E-175 |
| 抗体名： | Etbicyphat |
| 抗体英文名： | Etbicyphat |
| 靶点： | 见官方网站 |
| 浓度： | 见官方网站 |
| 应用范围： | 见官方网站 |
| 宿主： | Synthetic |
| 供应商： | 上海信裕生物科技有限公司 |
| 数量： | 大量 |
| 级别： | 高 |
| 目录编号： | E-175 |
| 抗原来源： | Synthetic |
| 保质期： | 6个月 |
| 适应物种： | 见官方网站 |
| 标记物： | 见官方网站 |
| 克隆性： | 否 |
| 保存条件： | -20°C |
| 形态： | 液体或冻干粉 |
| 亚型： | 见官方网站 |
| 免疫原： | 见官方网站 |
| 规格： | 50 mg, 100 mg, 250 mg, 500 mg |
Etbicyphat
TMPP, Trimethylopropane phosphate, Ethyl bicyclic phosphateAn Antagonist of GABA(A) Receptors
Cat #: E-175
Sizes: 50 mg, 100 mg, 250 mg, 500 mg
Source: Synthetic
MW: 178.12 Da.
Target: GABA(A) receptors
CLICK HERE TO RECEIVE A 50 mg FREE TRIAL SAMPLE!
Etbicyphat, also called trimethylopropane phosphate, is a synthetic convulsing compound that acts as a potent antagonist of GABA(A) receptors. TMPP acts through binding to the picrotoxinin and benzodiazepine receptor sites of the GABA(A) ionophore complex. TMPP is eliminated through the urine with no evidence of phase I or phase II metabolism and shows rapid clearance from the blood system1,2.
Several studies showed that infusion of TMPP into the nucleus accumbens of adult rats induces subclinical seizures and hyperlocomotor activity3.
GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system and play an important role in inhibiting cell excitation in the central nervous system. The GABA(A) receptor is a major target of antiseizure drugs4.
Alomone Labs is pleased to offer Etbicyphat (#E-175).
EtbicyphatReferences
- Rijal, S.O. and Gross, G.W. (2008) J. Neurosci. Methods 173, 183.
- Rossi, J. et al. (2001) Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1323.
- Rossi, J. et al. (1998) Drug Metab Dispos. 26,1058.
- Lindsey, J.W. et al. (1998) Neurotoxicology 19, 215.
- Pomara, N. et al. (2015) Prog. Neuropsychopharmacol Biol. Psychiatry 56, 35.
- Our Bioassay
- Specifications
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Alomone Labs Etbicyphat inhibits GABA(A) receptors expressed in Xenopus oocytes.
Representative time course of GABA(A) α1/β2 current, activated by a continuous application (top dotted line) of 0.1 µM γ-aminobutyric acid (#G-110), and inhibited by 2 µM and 10 µM Etbicyphat (#E-175), as indicated (bar), at a holding potential of -60 mV.
Purity>98%.
Effective concentration0.5-50 µM.
Chemical name4-Ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide.
Molecular formulaC6H11O4P.
CAS number1005-93-2.
ActivityEtbicyphat, an ethyl bicyclophosphate organophosphorous compound, is a GABA receptor antagonist (KB = 3.98 µM for GABA(A) receptors),1 a blocker of neuronal voltage and GABA dependent Cl- currents, and a potent convulsant (≥0.4 mg/kg IP in rats) 2,3.
Storage before reconstitutionProduct before reconstitution should be stored at room temperature.
ReconstitutionSoluble in water. Centrifuge before use (10000 x g, 5 min).
Storage after reconstitutionUp to three months at -20°C.
