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MicroVue CICP EIA*| 货号： | ESD-003 |
| 抗体名： | NaV1.8 Channel Deluxe Research Pack |
| 抗体英文名： | NaV1.8 Channel Deluxe Research Pack |
| 靶点： | 见官方网站 |
| 浓度： | 见官方网站 |
| 应用范围： | 见官方网站 |
| 宿主： | 见说明书 |
| 供应商： | 上海信裕生物科技有限公司 |
| 数量： | 大量 |
| 级别： | 高 |
| 目录编号： | ESD-003 |
| 抗原来源： | 见说明书 |
| 保质期： | 6个月 |
| 适应物种： | 见官方网站 |
| 标记物： | 见官方网站 |
| 克隆性： | 否 |
| 保存条件： | -20°C |
| 形态： | 液体或冻干粉 |
| 亚型： | 见官方网站 |
| 免疫原： | 见官方网站 |
| 规格： | 11 Vials |
NaV1.8 Channel Deluxe Research Pack
All You Need for NaV1.8 Channel ResearchAll You Need for NaV1.8 Channel Research
Cat #: ESD-003
11 Vials
Alomone Labs is pleased to offer the NaV1.8 Channel Deluxe Research Pack (#ESD-003). The Research Pack contains all you need for NaV1.8 research: Antibodies recognizing different domains of the channel and NaV1.8 blockers, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-NaV1.8 | ASC-016 | 1 x 0.2 ml |
Anti-NaV1.8 (extracellular) | ASC-028 | 1 x 0.2 ml |
Anti-NaV1.8-ATTO-594 | ASC-016-AR | 1 x 50 µl |
Guinea pig Anti-NaV1.8 | AGP-029 | 1 x 0.2 ml |
A-803467 | A-105 | 1 x 50 mg |
Tolperisone hydrochloride | T-115 | 1 x 100 mg |
VSTX3 | STT-350 | 1 x 0.1 mg |
Note A guinea pig polyclonal antibody (#AGP-029) is included in this Research Pack. Please take into account when reacting with a secondary antibody.
Scientific Background
Voltage-gated Na+ channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-1.9. 2-3 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 Expression of the α subunit isoform is developmentally and tissue specific.
Two TTX-resistant NaV channels are expressed in dorsal root ganglion (DRG) neurons, NaV1.8 and NaV1.9. The NaV1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.
Recently, involvement of NaV1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6
NaV1.8 Channel Deluxe Research PackReferences
- Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
- Renganathan, M. et al. (2003) Brain Res. 959, 235.
- Fang, X. et al. (2002) J. Neurosci. 22, 7425.
- Wu, L. et al. (2002) Neuro. Report 13, 2547.
- Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
- Fjell, J. et al. (2000) Neuro. Report 11, 199.
