Apoptosis PCR Array 凋亡基因表达PCR芯片 384孔板

凋亡基因表达PCR芯片（384HT）可以用于检测370个凋亡或细胞程序性死亡相关的关键基因。该芯片涵盖的基因包括：TNF配体及相应受体， bcl-2蛋白家族，BIRC结构域蛋白，CARD结构域蛋白，死亡效应结构域蛋白，TRAF结构域蛋白和半胱天冬酶。这370个基因可以按功能分类，分别在凋亡，DNA损失，氧化应激，或胞内和胞外信号等过程中发挥作用。使用该芯片研究者可以方便并且可信地对凋亡相关基因的表达进行集中分析。
CasPAses & Regulators: CasPAses: CASP1, CASP10, CASP14, CASP2, CASP3, CASP4, CASP5, CASP6, CASP7, CASP8, CASP9, CFLAR (CASPER), CRADD, CARD18, CARD17, MALT1, PYCARD, RFWD2 (COP1).
CasPAse Activators: AIFM3, APAF1, BAX, BBC3, BCL2L10, BCL2L13, CASP1, CASP8AP2, CASP9, COL4A3, CYCS, DIABLO (SMAC), EIF2AK3, F2, F2R, FOXL2, HIP1, HSPE1, IFNB1, IFT57, LCK, MAP3K5, MOAP1, MTCH1, MYC, NLRC4, NLRP1, NLRP12, NLRP2, NLRP3, NOD1, PMAIP1, PYCARD, STAT1, TNFRSF10A, TNFRSF10B, TNFSF15, TP53, TPD52L1, VCP.
CasPAse Inhibitors: BIRC5, CD27 (TNFRSF7), DHCR24, HBXIP, IFI6, SFN, TNFAIP8, TNFSF14, TRIAP1, XIAP.
Anti-Apoptosis: Positive Regulation: BCL2L1 (BCL-X), BRE, CD28, ERC1, MAPK8IP2, OPA1, PRKAA1, RASA1.
Negative Regulation: PIK3R2, RTN4, TNFAIP8.
Other genes: AATF, AKT1, ALOX12, ANXA1, ANXA4, API5, ATF5, AVEN, AZU1, BAG1, BAG3, BAG4, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L2, BDNF, BECN1, BFAR, BIRC2, BIRC3, XIAP, BIRC5, BIRC6, BIRC7, BIRC8, BNIP1, BNIP2, BNIP3, BRAF, CASP2, CBX4, CCL2, CD27, CD40LG, CEBPB, CFDP1, CFL1, CFLAR, CRYAA, CRYAB, DAD1, DDAH2, DHCR24, EEF1A2, FAIM, FAIM2, FAS, FOXO1, GDNF, GFRAL, GLO1, GSTP1, HBXIP, HTT, HDAC1, HDAC3, HIPK3, HMGB1, HSP90B1, HSPA1B, HSPA9, HSPB1, HTATIP2, IER3, IFI6, IGF1R, IL10, IL1A, IL2, IL31RA, MALT1, MCL1, MKL1, MPO, MTL5, MYBL2, MYO18A, NAIP, NFKB1, NME5, NOL3, NOTCH2, NPM1, NRG2, NTF3, PAK7, PAX7, PEA15, PIK3CA, PIM2, POGK, POLB, PRDX2, PRKCZ, PRLR, PROK2, PSEN1, RELA, RNF7, SEMA4D, SERPINB2 (PAI-2), SERPINB9, SFRP1, SH3GLB1, SNCA, SOCS2, SOCS3, SON, SPHK1, SPP1, STAMBP, TAX1BP1, TBX3, TGFB1, TIAF1, TNF, TNFAIP3, TNFAIP8, TNFRSF10D, TNFRSF18, TNFRSF6B, TNFSF18, TPT1, TRIAP1, TSC22D3, TMX1, VEGFA, VHL, YWHAZ, ZC3HC1.
Induction of Apoptosis: Death domain receptors: BID, CRADD, DAXX, DEDD2, FADD, IL18, TNF, TNFRSF10B.
DNA damage: ABL1, AIFM1, BCL3, BRCA1, CHEK2 (RAD53), CIDEA, CIDEB,
DYRK2, IFI16, MBD4, MSH6, PCBP4, PML, SFN, TP53, TP73.
Oxidative stress: GPX1, PRODH, RNF7, TP53I3
Extracellular signals: ADORA1, BTK, CASP8AP2, CD28, CD38, CD5, CFLAR (CASPER), DAP, DAP3, DAPK1, DPF2, FASTK, MAP3K5, NDUFA13, PDCD6, PRKCA, RIPK3, SPN, TIMP3, TNFRSF25.
Intracellular signals: CDKN1A, CUL1, CUL2, CUL3, CUL4A, CUL5, HIPK2, MYC, SART1.
Other genes: ACVR1B, AIFM2, AIFM3, ALOX15B, APOE, BAD, BAK1, BAX, BBC3, BCL10, BCL2L11, BCL2L13, BCLAF1, BIK, BNIP1, BNIP3, BNIP3L, BOK, CASP10, CASP3, CASP4, CASP6, CD2, CD27, CD70, CEBPB, CIDEC, COL4A3, DAPK2, DAPK3, DCC, DDX20, DEDD, DIABLO (SMAC), EI24, ERCC2, ERCC3 (XPB), ERN1, ERN2, FAS, FASLG, FEM1B, FOXL2, FOXO3, HRK, HTATIP2, IFNA2, IFNB1, IFNG, IKBKG, IKBIP, IL19, INHA, INHBA, JMY, LALBA, LCK, LTA, MAL, MAP3K10, MAPK1, MX1, NDUFS3, NGFR, NLRP1, NLRP3, NME3, NOTCH2, NOX5, NUDT2, NUPR1, PDCD5, PLAGL1, PLAGL2, PLEKHF1, PLG, PMAIP1, PPP1R13B, PPP2CA, PPP2R1A, PPP2R1B, PRKCE, PRKRA, PRUNE2, PTEN, PTH, PYCARD, RPS3A, RUNX3, S100B, SAP30BP, SERINC3, SIPA1, SMNDC1, SST, SSTR3, STK17A, STK17B, TBX5, TIA1, TIAL1, TLR2, TNFRSF10A, TNFRSF19, TNFRSF9, TNFSF10, TNFSF14, TNFSF8, TP53BP2, TP63, TPD52L1, TRADD, TRAF3, TRAIP, UNC13B, UTP11L, ZNF443. TNF Domain: EDA, FASLG (TNFSF6), LTA, LTB, TNF, TNFSF10, TNFSF14, TNFSF15, TNFSF8. TNFR Domain: CD27 (TNFRSF7), CD40 (TNFRSF5), FAS (TNFRSF6), LTBR, NGFR, TNFRSF10A, TNFRSF10B, TNFRSF10D, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF6B, TNFRSF8, TNFRSF9.
BCL2 and BAG Domain: BAG1, BAG3, BAG4, BAX, BCL2, BCL2A1, BCL2L1, BCL2L10, BCL2L13, BCL2L2, MCL1.
BIR Domain: BIRC2 (c-IAP2), BIRC3 (c-IAP3), BIRC5, BIRC6, BIRC7, BIRC8, NAIP (BIRC1), XIAP.
CARD Domain: APAF1, BCL10, BIRC2 (c-IAP2), BIRC3 (c-IAP1), CARD10, CARD11, CARD14, CARD6, CARD9, CASP1, CASP2, CASP4, CASP5, CASP9, CRADD, CARD18, CARD17, NLRP1, NOD1, NOD2, NOL3, PYCARD, RFWD2 (COP1), RIPK2.
DEATH Domain: CRADD, DAPK1, EDAR, FADD, PIDD, MALT1, NFKB1, NFKB2, NGFR, RIPK1, TNFRSF10A, TNFRSF10B, TNFRSF1A, TNFRSF21, TNFRSF25, TRADD.
TRAF Domain: TRAF2, TRAF3, TRAF5, TRAF7.
Other Regulators of Apoptosis: BCL6, CEBPG, DBP, DDIT3 (GADD153/CHOP), GRM4, LGALS1, MADD, MAPK8, NKX3-2, POU4F1, PROP1, RARG, STAT5A, STAT5B, TBK1, TDGF1, TRAF6, ZAK.