点击图片查看原图
Tie-2 ELISA检测试剂盒，elisa试剂盒
小鼠(AQP-4)elisa试剂盒厂家
AP-Goat Anti- Rat IgG (H+L)
[VIP第1年] 指数:2
通过奉贤区市场监管局认证 
Sorafenib TosylateS1
TaKaRa MiniBEST FFPE
sgRNA的体外转录和筛
杭州四季青 无噬菌体
HyClone 磷酸盐缓冲液
DMEM/F12(1:1)液体培
LZS11131 人中性粒细
焦碳酸二乙酯(液体)E1| 货号： | S1657 |
| 供应商： | 上海善然生物科技有限公司 |
| 数量： | 大量 |
| 保存条件： | 低温 |
| 规格： | 50mg |
| Enalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments. [1] Enalaprilat has the strong inhibitory effect on Aβ42-to-Aβ40-converting activity found in the N-domain of ACE, exhibiting a 10-fold lower IC50 (0.003~0.01 μM) than captopril (0.03~0.1 μM). [2] Enalaprilat (100 nM) blocks protein kinase C epsilon by directly activating bradykinin B1 receptor at the canonical Zn2+ binding site, leading to prolonged nitric oxide (NO) production in cytokine-treated human lung microvascular endothelial cells. [3] Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM. [4] | ||||||
温馨提示：不可用于临床治疗。
