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WBKLS0100 Immobilon | 货号： | BE3173-50 |
| 抗体英文名： | Cleaved PARP Mouse Monoclonal Antibody |
| 克隆性： | 否 |
| 保存条件： | -20℃ |
| 形态： | 液体 |
| 规格： | 50μl/支 |
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate.
Product Name:Cleaved PARP Mouse Monoclonal Antibody
Clone Number: M4
Isotype: IgG1
Storage Buffer :PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol
Storage instructions:-20°C. Do not aliquot the antibody
Recommended dilutions: WB: 1:1,000-3,000
Optimal dilutions should be determined by the end user.
Specificity: Antibody can detects endogenous pro and active PARP protein.
Alternative Names:PARP-1, Poly(ADP ribose) polymerase 1, sPARP1,ADPRT1, ADP ribosyltransferase NAD(+)
Molecular Weight:116KD（Pro） 89KD（Active）
Form: Liquid
Reactivity:H
Western blot analysis of 1) Jurkat ,2) Hela, with BE3173 diluted at 1:2,000
