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SCILOGEX赛洛捷克 MS-| 货号： | IPA1004-0005MG |
| 保存条件： | -20℃ |
| CAS号： | 371935-74-9 |
| 供应商： | 上海伟进生物科技有限公司 |
| 数量： | 10 |
| 英文名： | PI-103 |
| 保质期： | 2 years |
| 规格： | 5mg |
Biological Activity
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β and p110γ, respectively. It shows little activity against a wide array of protein kinases at 10 mM [1]. PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity [2].In blast cells, PI-103 suppresses leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells [3].
Chemical Properties
| Cas No.: 371935-74-9 | M. Wt.: 348.36 |
| Formula: C19H16N4O3 | Purity: >99% |
| Synonym: PI 103 | |
| Chemical Name: 3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol | |
| Appearance: Off white to white solid | |
| Solubility: Soluble in DMSO at 10 mg/ml, slightly soluble in water. | |
| Storage: Store powder at -20 ºC for the stability up to two years, keep desiccated. | |
