货号: | IPA1004-0005MG |
保存条件: | -20℃ |
CAS号: | 371935-74-9 |
供应商: | 上海伟进生物科技有限公司 |
数量: | 10 |
英文名: | PI-103 |
保质期: | 2 years |
规格: | 5mg |
Biological Activity
PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β and p110γ, respectively. It shows little activity against a wide array of protein kinases at 10 mM [1]. PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity [2].In blast cells, PI-103 suppresses leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells [3].
Chemical Properties
Cas No.: 371935-74-9 | M. Wt.: 348.36 |
Formula: C19H16N4O3 | Purity: >99% |
Synonym: PI 103 | |
Chemical Name: 3-(4-(4-Morpholinyl)pyrido[3’,2’:4,5]furo[3,2-d]pyrimidin-2-yl)phenol | |
Appearance: Off white to white solid | |
Solubility: Soluble in DMSO at 10 mg/ml, slightly soluble in water. | |
Storage: Store powder at -20 ºC for the stability up to two years, keep desiccated. |