货号: | WL01996 |
抗体名: | Occludin抗体 |
抗体英文名: | Occludin |
浓度: | >1mg/ml |
应用范围: | WB,IHC |
宿主: | 兔 |
适应物种: | H,M,R |
标记物: | 无 |
克隆性: | 否 |
保存条件: | -20℃ |
形态: | 液体 |
亚型: | IgG |
规格: | 50μl(>50μg) |
本公司所有一抗,50μl(>50μg)现价450元/支,全部现货,均提供20μl免费试用装,详情请点击免费试用
产品货号 | WL01996 | |||
产品名称 | Occludin Antibody | |||
预测分子量 | 60-82kDa | |||
别名 | OCLN; BLCPMG; Tight junction protein occludin | |||
浓度 | >1 mg/ml | |||
免疫原 | Occludin重组蛋白 | |||
抗体来源 | 兔 | |||
特异性 | 抗人,小鼠,大鼠 | |||
克隆类型 | 多克隆抗体 | |||
产品应用 | WB;IHC | |||
成分 | 亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,NaN3<0.02% | |||
保存条件 | -20℃保存 | |||
背景资料 | Occludin is an integral membrane protein closely associated with the tight junctions of epithelial and endothelial cells. Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of occludin. Expression of occludin is up-regulated by polyunsaturated fatty acids, increasing transendothelial cell resistance and reducing cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction. | |||
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