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-无内毒素超大量质粒提取试剂盒
NVP-BAW2881
Abcam,ab30178,Brain: hippocampus (H
[VIP第1年] 指数:2
通过浦东新区市场监管局认证 
4'-6-DIAMIDINO-
MC3R-CRE-BLA CHO-K1 
LightShift Chemilumi| 货号： | IMT1001-100MG |
| 供应商： | 前尘生物 |
| 数量： | 大量 |
| 英文名： | Rapamycin |
| CAS号： | 53123-88-9 |
| 保存条件： | -20°C |
| 规格： | 100mg |
Rapamycin 雷帕霉素 Assay: >99%
Rapamycin雷帕霉素是一种临床使用的免疫抑制剂，并通过抑制mTOR信号通路而调节细胞的存活，增殖，以及迁移等。在包括小鼠、果蝇、线虫等在内的多种模式生物上，rapamycin已被证明能够显著延长生物体的寿命。
产品说明：
Chemical Name: Rapamycin
Synonyms: Sirolimus, RAPA, Rapamune, AY-22989, NSC 226080, LCP-Siro, SILA 9268A
CAS Registry Number: 53123-88-9
Molecular Weight: 914.17
Molecular Formula: C51H79NO13
产品应用：
一种新型大环内酯类免疫抑制药物。通过与相应免疫嗜素RMBP结合抑制细胞周期G0期和G1期，阻断G1进入S期而发挥作用，其效应为：①抑制T和B细胞增殖；②抑制IL-1、IL-2、IL-6和IFN-γ诱导的淋巴细胞增殖；③抑制IgG和供者特异性抗体(细胞毒抗体)产生；④抑制单核细胞增殖。可用于抗移植排斥反应和治疗类风湿性关节炎、红斑狼疮等自身免疫病。
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin name is derived from the native word for Easter Island, Rapi Nui.
物理性质：
Form: solid powder
Color: white to off-white
Odor: none
Melting point/Melting range: 173-187ºC
Danger of explosion: none
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 50 mg/mL; soluble in ethanol at 50 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Solvent content: none
Organic solvents: soluble in DMSO at 50 mg/mL; soluble in ethanol at 50 mg/mL
Solubility: Rapamycin is soluble in DMSO and Methanol
注意事项：
Hazard Description: potent immunosuppresent; may cause irritation to eyes, skin, mucous membranes
产品信息：现货
订购信息：（原装进口，常备现货）
| 品 牌 | 产品名称 | CAS NO. | 产品货号 | 规 格 | 目录价（元） | 特价（元） | 库存 |
| Gene Operation | Rapamycin (mTOR inhibitor/免疫抑制剂） | 53123-88-9 | IPA1021-0010MG | 10 mg | 599.00 | 380.00 | 有 |
| 53123-88-9 | IPA1021-0050MG | 50mg | 1549.00 | 650.00 | 有 | ||
| 53123-88-9 | IPA1021-0100MG | 100mg | 2099.00 | 880.00 | 有 | ||
| 53123-88-9 | IPA1021-0500MG | 500mg | 5359.00 | 3320.00 | 有 | ||
| 53123-88-9 | IPA1021-0001G | 1g | 9889.00 | 4150.00 | 有 | ||
| 53123-88-9 | IPA1021-0002G | 2g | 17969.00 | 7540.00 | 有 | ||
| 53123-88-9 | IPA1021-0005G | 5g | 33949.00 | 14250.00 | 有 | ||
| 53123-88-9 | IPA1021-0010G | 10g | 63129.00 | 26500.00 | 有 |
GeneOperation公司的产品来自美国，纯度高于99%，能保证产品具有高品质低价格的优势。
目前使用GeneOperation的客户：同济大学、上海交通大学、中科院生化细胞研究所、第二军医大学、复旦大学、清华大学、北京大学、中科院动物所、广州生物与健康研究院和军科院等单位，干细胞研究的实验室比较多。
