mGlu Agonists试剂盒

概述

• 产品名称
  mGlu Agonists试剂盒
  参阅全部 Metabotropic glutamate receptor 试剂盒
• 特异性
  A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
  The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006). *Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water.
• 产品概述

  A collection of 7 agonists and modulators for a range of mGlu receptor subtypes. Products are freeze-dried as an exact weight so that addition of 1 ml or 0.5 ml of water provides a stock solution of 5 mM or 10 mM*, respectively.
  The kit contains (S)-3,5-DHPG (ab120007), (R,S)-CHPG sodium salt (ab120221), LY 379268 (ab120196), L-AP4 (ab120002), VU0155041 sodium salt (ab120248), AMN082 dihydrochloride (ab120011) and (S)-3,4-DCPG (ab120006). 

  *Please note that AMN082 dihydrochloride (ab120011) is only soluble to 5 mM in water. 

  Receptor

  Description. 

  mGlu_1,5 

  (S)-3,5-DHPG:

  Selective group I mGlu agonist. 

  Suggested Solvent: Water 

  mGlu₅ 

  (R,S)-CHPG sodium salt:

  Water soluble form of (R,S)-CHPG (ab120039), a selective mGlu₅ agonist. 

  Suggested Solvent: Water 

  mGlu_2,3 

  LY379268:

  Highly potent and systemically active mGlu₂ and mGlu₃ agonist. EC₅₀values are 2.69 and 4.48 nM for hmGlu₂ and hmGlu₃, respectively and displays > 80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain. 

  Suggested Solvent: Water 

  mGlu_4,6,7,8 (group III) 

  L-AP4:

  Selective group III mGlu receptor agonist. 

  Suggested Solvent: Water 

  mGlu₄ 

  VU0155041 sodium salt:

  Water soluble, positive allosteric selective modulator at mGluR₄ (EC₅₀values are 798 nM and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is water soluble and more potent. Active in behavioural models of Parkinsons Disease. 

  Suggested Solvent: Water 

  mGlu₇ 

  AMN082 dihydrochloride:

  Potent, selective, orally active and brain penetrant mGlu₇ receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC₅₀ = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu_{1, 2, 3, 4, 5, 6} and ₈ and ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu₇ receptor internalisation in dissociated hippocampal neurones. 

  Suggested Solvent: Water (5 mM) / DMSO (10 mM) 

  mGlu₈ 

  (S)-3,4-DCPG: 

  Potent, selective mGlu_8a agonist (EC₅₀ = 31 nM). Displays > 100-fold selectivity over mGlu₇. Systemically active in vivo.

  Suggested Solvent: Water

• 说明

  KIT

性能

• 存放说明
  Store at -20°C. Please refer to protocols.