货号: | ONI-171823 |
CAS号: | 861875-60-7 |
供应商: | 美国 |
数量: | 1322.0 |
英文名: | NVP-BAW2881,NVP-BAW-2881,,NVP-BAW 2881 |
保质期: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
保存条件: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
规格: | (5mg/100mg/872mg) |
BAW2881 is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit chronic and acute skin inflammation. target: VEGFR IC 50: 37 nmol/L In vitro: BAW2881 block VEGF-A-induce proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) and lymphatic endothelial cells (LECs) In vivo: In a transgenic mouse model of psoriasis, NVP-BAW2881 reduce the number of blood and lymphatic vessels and infiltrating leukocytes in the skin, and normalize the epidermal architecture. NVP-BAW2881 also display strong anti-inflammatory effects in models of acute inflammation. Pretreatment with topical NVP-BAW2881 significantly inhibited VEGF-A-induced vascular permeability in the skin of pigs and mice. NVP-BAW2881 can dissolve in polyethylene glycol-200 and orally administered to mice in a dose of 25 mg/kg/day in 10 ml/kg.
温馨提示:不可用于临床治疗。
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