货号: | ONI-171389 |
CAS号: | 1226895-20-0 |
供应商: | 美国 |
数量: | 888.0 |
英文名: | ATB346;ATB 346 |
保质期: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
保存条件: | 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO |
规格: | (5mg/100mg/438mg) |
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity. IC50 value: Target: COX-2 ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but produced negligible damage in the stomach and intestine, Unlike naproxen and celecoxib, ATB-346 accelerated healing of pre-existing gastric ulcers. In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB-346 did not elevate blood pressure in hypertensive rats [1]. Treatement with ATB-346 exhibited a significantly more rapid and sustained recovery of motor function, achieving greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI [2].
温馨提示:不可用于临床治疗。
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