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SAR407899
PENTOSTATIN| 货号： | R17011 |
| CAS号： | 521984-48-5 |
| 供应商： | 上海芮晖化工 |
| 数量： | 0.5g |
| 英文名： | SIS3 HCl |
| 保质期： | 两年 |
| 保存条件： | 冷冻 |
| 规格： | 10mg/25mg/100mg |
SIS3是一个强的和选择性的Smad3抑制剂，也是强的Nox4启动子的调节器。
生物活性
SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter.
target: Smad3
SIS3 Reduces the TGF-β1-Dependent Increase in Phosphorylation and DNA Binding of Smad3. SIS3 has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. SIS3 can block excessive ECM production from the TGF-β1-treated normal fibroblasts and scleroderma fibroblasts, the model of cells with autocrine TGF-β signaling in vitro.
化学信息
| 分子量 | 489.99 | 储存条件 | |
|---|---|---|---|
| 分子式 | C₂₈H₂₈ClN₃O₃ | ||
| CAS号 | 521984-48-5 | ||
| 溶剂/溶解度 | DMSO: ≥ 30 mg/mL |
相关文献
[1]. Boudreau HE et al. Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in TGF-β-mediated migration of human lung and breast epithelial cells. Br J Cancer. 2014 May 13;110(10):2569-82.
[2]. Jinnin M et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607.
[3]. Di Bernardini E et al. Endothelial lineage differentiation from induced pluripotent stem cells is regulated by microRNA-21 and transforming growth factor β2 (TGF-β2) pathways. J Biol Chem. 2014 Feb 7;289(6):3383-93.
