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PENTOSTATIN| 货号： | R10838 |
| CAS号： | 83280-65-3 |
| 规格： | 5mg/50mg/500mg |
| Description | Napabucasin is an orally available Stat3 and cancer cell stemness inhibitor. | |
|---|---|---|
| Targets |
| |
| In vitro | Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells. | |
| In vivo | In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis |
Solubility (25°C)
| In vitro | DMSO | 10 mg/mL (41.63 mM) |
|---|---|---|
| Water | <1 mg/mL | |
| Ethanol | <1 mg/mL | |
| In vivo | 5% DMSO+Corn oil | 1mg/mL |
Chemical Information
| Molecular Weight | 240.21 |
|---|---|
| Formula | C14H8O4 |
| CAS No. | 83280-65-3 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
温馨提示：不可用于临床治疗。
