巨噬细胞去除剂（阴离子）

Clophosome®-A- Clodronate Liposomes (Anionic)

Clophosome®-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio.  Free clodronate is cleaned out and the liposomal encapsulation efficiency of clodronate is more than 90%. Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles. It is manufactured sterile for long term shelf-life. 

The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved > 90% depletion in splenic macrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications.

Specifications

Product name: Clophosome®-A

Product code: F70101C-A

Active: clodronat disodium. CAS: 22560-50-5, 7 mg/mL

Lipid composition: phosphatidylglycerol, phosphatidylcholine and cholesterol

Bulk solution: phosphate buffered sucrose (20mM sodium phosphate, 10% sucrose), pH 7.0-7.5

Shelf-life: 6 months guaranteed for unopened vials


Clophosome-氯弗松（Clodronate Liposomes-氯膦酸二钠脂质体）
 
Formumax Scientific公司生产的系列产品Clophosome（氯弗松）和Clophosome-A（阴离子氯弗松）是目前市场上最理想的用于高效巨噬细胞耗竭的氯膦酸二钠脂质体。此组产品具有活性高、有效期长、使用方便、无菌无毒等诸多优越性能。该剂型优点包括高浓度，高包封率，不黏稠，无沉淀，易于注射。尤其是优化后的配方保证此产品即使在冰箱中储存数月后仍能保持其高活性和均匀无沉淀状态。我们提供的6个月产品保质期比其他厂家的同类产品高出一倍以上。该组产品适用于多种给药途径，包括静脉注射、皮下注射、气管给药和直接注射等。在单次静脉注射或腹腔注射0.2ml Clophosome后自24小时起脾脏和肝脏中巨噬细胞耗竭可持续一周保持在80%以上。如果每4天注射一次，高效巨噬细胞耗竭可持续数周之久。Formumax Scientific公司独家转型产品Clophosome-A，除保持了Clophosome所有优点之外，更使得单次注射后巨噬细胞耗竭率高达90%以上。深受广大科研用户的欢迎。此组产品是免疫学、肿瘤学和其他生物学领域必不可少的科研工具。
 
Formumax Scientific公司成立于2008年，位于世界高科技和生物科技中心美国加州硅谷
Formumax Scientific公司在纳米脂质体药物传送领域处于国际领先地位
Formumax Scientific公司拥有一支世界一流水准的技术团队，具有三十年药物传送研发经验
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