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Antibodies for Accurate Detection of Phospho-Proteins

Phosphoproteins comprise 10-20% of the proteome, and are critical elements in human diseases such as Alzheimer's and cancer. The detection and quantitation of phosphoproteins is of great utility in further understanding the role of protein phosphorylation in cellular processes and in the progression of Human diseases. Abbiotec’s phospho-specific antibodies are specifically designed to eliminate cross-reactivity and to produce results of the highest quality.  
 

NEW PHOSPHO-SPECIFIC ANTIBODY: YAP1 (Ser94) Antibody

YAP (Yes-associated protein) is a transcription coactivator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and in organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteosomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. Dysregulation of the Hippo-YAP pathway is frequently observed in human cancers. AMPK directly phosphorylates YAP at Ser94, a residue essential for the interaction with TEAD, thus disrupting the YAP-TEAD interaction.

                       

Download our Phospho-Specific Antibodies Brochure here.

14-3-3 (Ser58)                                  DARP-32 (Thr34)                           mGluR-7 (Ser862)

5-Lipoxygenase (Ser523)               Dynamin (Ser774)                          Munc-18 (Ser515)
 
Alpha Synuclein (Ser129)               Elk-1 (Ser383)                                NMDAR2B (Tyr1252)

AQP2 (Ser261)                                 EphB (Tyr331)                                p53 (Ser392)

ATF2 (Ser 490/498)                         GABABR1 (Ser923)                        PAK-1/2/3 (Thr402)

Beclin-1 (Ser15)                              Gap-43 (Ser41)                               Parkin (Ser378)
                                                     
Beta-Catenin (Ser33/37)                 GluR1 (Ser831)                               PLK-1 (Thr210)

CaMK-II (Thr286)                             GSK3B (Ser9)                                 Raf-1 (Ser301)
                                                         
Cdc2 (Tyr15)                                    KCNC1 (Ser503)                            Synapsin (Ser 62/67)

Connexin-43 (Ser368)                     MeCP2 (Ser80)                               TAO2 (Ser181)
                                  
CREB (Ser133)                                MEK1 (Thr292)                                Tau (Ser416)

Contact our Customer Service Dept for comprehensive product listing and availability. 

SPECIAL OFFER FOR OUR SUBSCRIBERS -  Until October 15, 2015 - Save 10% on the phosphospecific antibodies. Use promo code ENEWS0915 at time of order.  Terms and conditions apply. 

PRODUCT CITATIONS - For a comprehensive list of product citations, refer to the citation webpage.

Cat. No. 250590 CD31 Antibody for IHC in mouse iPS cells
Chen T et al. 2015. Stem cells. PMID 25535084. MicroRNA-199b modulates vascular cell fate during iPS cell differentiation by targeting the notch ligand jagged1 and enhancing VEGF signaling.

Cat. No. 250752 MMP-2 Antibody for WB in human osteosarcoma cells
Zhu J et al. 2015. Mol Med Rep. PMID 25634369. Activin A regulates proliferation, invasion and migration in osteosarcoma cells.

Cat. No. 251396 GDNF Antibody for WB in human spinal stem cells
Lunn JS et al. 2015. Stem Cells. PMID 25532472. Autocrine production of IGF-I increases stem cell-mediated neuroprotection.

Cat. No. 254515 Beclin-1 (Ser15) Antibody for WB in mouse brain tissues
Tanji K et. al. 2015. Biochem Biophys Res Commun. PMID 26299928. Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.

 

If you need an antibody specific for a phosphorylation site in your protein sequence like Dr. R. Russell did, ABBIOTEC offers custom polyclonal and monoclonal antibody production services t o help accelerate your project:
Prof. M.G. Finn (Georgia Tech): "I have been very impressed with the care and insights you have provided throughout the project".
Dr. J. Washburn (Univ. of Oklahoma HSC): "You have been very knowledgeable". 
 

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ABBIOTEC is a biotech company founded in 2007 in San Diego, California, a renowned world-class Life Sciences cluster that hosts more than 1,500 research labs and biotech companies. We are focused on developing, producing and commercializing next generation antibodies and unique reagents for the Life Sciences research community including the diagnostic and pharmaceutical markets.
ABBIOTEC offers years of expertise making antibodies and assay kits for catalog products to the scientific and biotech community. With our recently upgraded animal facility, we offer polyclonal antibody production in small and large animals (rabbits, goats, llama) as well as monoclonal antibody production (mice and rats). Because peptide chemistry is an essential tool to biology, we offer custom peptide synthesis services for research-grade peptides.

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