Disease: Colorectal adenocarcinoma Origin: Established from a primary adenocarcinoma of the colon Species:Homo sapiens Tissue:Colon Morphology:Epithelial Properties:Adherent Cytogenic data:Tumorigenic; The stemline chromosome number is hypotriploid Patient:Male, Caucasian, 50 yrs of age Medium:L15 + 10% FBS Subculture:1:5 to 1:10 using using 0.25% trypsin or trypsin/EDTA, w/ or w/o 5% CO2; 37°C Freezing Medium:Complete culture medium supplemented with 5% (v/v) DMSO Biosafety Level: I Sterility:Bacteria: Negative Yeast: Negative Mycoplasma: Negative Pathogens:HIV: Negative Hepatitis B: Negative Hepatitis C: Negative Protein Expression: epidermal growth factor (EGF), HLA A2, B8, B17 Isoenzymes: G6PD, B; PGM1, 2; PGM3, 1; 6PGD, A; PEP-D, 1; ES-D, 1 DNA Profile (STR): Amelogenin: X,X; CSF1PO: 13,14; D13S317: 12; D16S539: 13; D5S818: 13; D7S820: 8; THO1: 8; TPOX: 11; vWA: 16; D3S1358: 15; D21S11: 30,30.2; D18S51: 13; Penta E: 10; Penta D: 9,15; D8S1179: 13; FGA: 24 Mutations in SW480 CellsRelated cells by Organ:Caco-2 cells DLD-1 cells HCA-7 cells HCT-116 cells SW480 cells HT-29 cells LS-180 cells SW620 cells T84 cells SW48 cells RKO cells SNU-407 cells SNU-503 cells LS-174T cells LoVo cells HCT15 cells References for SW480 cells:1. Hartman, J., Edvardsson, K., Lindberg, K., Zhao, C., Williams, C., Strom, A., and Gustafsson, J. A. Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res, 69: 6100-6106, 2009. 2. Kong, C. K., Lam, W. S., Chiu, L. C., Ooi, V. E., Sun, S. S., and Wong, Y. S. A rice bran polyphenol, cycloartenyl ferulate, elicits apoptosis in human colorectal adenocarcinoma SW480 and sensitizes metastatic SW620 cells to TRAIL-induced apoptosis. Biochem Pharmacol, 77: 1487-1496, 2009. 3. Liao, Q. J., Su, J., He, J., Song, Y., Tang, H. L., and Su, Q. Effect of diallyl disulfide on cell cycle arrest of human colon cancer SW480 cells. Ai Zheng, 28: 138-141, 2009. 4. Shan, B. E., Wang, M. X., and Li, R. Q. Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest, 27: 604-612, 2009. 5. Tadlaoui Hbibi, A., Laguillier, C., Souissi, I., Lesage, D., Le Coquil, S., Cao, A., Metelev, V., Baran-Marszak, F., and Fagard, R. Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide--interference with interferon-gamma-STAT1-mediated killing. Febs J, 276: 2505-2515, 2009. 6. Yavari, K., Taghikhani, M., Maragheh, M. G., Mesbah-Namin, S. A., and Babaei, M. H. Knockdown of IGF-IR by RNAi inhibits SW480 colon cancer cells growth in vitro. Arch Med Res, 40: 235-240, 2009.