货号: | ADG886 |
样本: | 100 μl |
应用: | 血浆 |
检测方法: | ELISA |
检测限: | 0.5 U/ml |
供应商: | American Diagnostica GmbH |
数量: | 大量 |
规格: | 96 wells |
The IMUCLONE® vWF:CB ELISA kit is an enzyme-linked immunosorbent assay for the differential diagnosis of von Willebrand Factor-Collagen Binding (typing) in human citrate plasma.
INTRODUCTION
Von Willebrand Factor (vWF) is a large, multi-functional glycoprotein with a key position in primary hemostasis. It exists as a multimere and has several functions: It mediates platelet aggregation via adhesion of the platelet membrane receptors following platelet activation.
In primary hemostasis it acts as a mediator in platelet adhesion to the subendothelium. Platelet aggregation is normally determined to characterize the adhering properties (parameter: Ristocetin-dependent platelet aggregation).
However, it does not reflect the physiological state and function of vWF. The binding of vWF to collagen is used as a tool for measuring the adherent properties of vWF [1, 2].