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MicroVue CICP EIA*| 货号： | ESB-950 |
| 抗体名： | Angiotensin II Receptor Basic Research Pack |
| 抗体英文名： | Angiotensin II Receptor Basic Research Pack |
| 靶点： | 见官方网站 |
| 浓度： | 见官方网站 |
| 应用范围： | 见官方网站 |
| 宿主： | 见说明书 |
| 供应商： | 上海信裕生物科技有限公司 |
| 数量： | 大量 |
| 级别： | 高 |
| 目录编号： | ESB-950 |
| 抗原来源： | 见说明书 |
| 保质期： | 6个月 |
| 适应物种： | 见官方网站 |
| 标记物： | 见官方网站 |
| 克隆性： | 否 |
| 保存条件： | -20°C |
| 形态： | 液体或冻干粉 |
| 亚型： | 见官方网站 |
| 免疫原： | 见官方网站 |
| 规格： | 8 Vials |
Angiotensin II Receptor Basic Research Pack
All You Need for Angiotensin II Receptor ResearchCat #: ESB-950
8 Vials
Alomone Labs is pleased to offer the Angiotensin II Receptor Basic Research Pack (#ESB-950). The Research Pack contains all you need for angiotensin II receptor research, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-Angiotensin II Receptor Type-1 (extracellular) | AAR-011 | 1 x 0.2 ml |
Anti-Angiotensin II Receptor Type-2 (extracellular) | AAR-012 | 1 x 0.2 ml |
Angiotensin A (1-8) | SPA-105 | 1 x 10 mg |
Angiotensin II acetate | SPA-165 | 1 x 50 mg |
Azilsartan | A-245 | 1 x 25 mg |
PD 123319 ditrifluoroacetate | P-245 | 1 x 10 mg |
Scientific Background
Ang II is the peptide hormone that generates most of the known effects of the renin-angiotensin system (RAS). Ang II is generated from the angiotensinogen protein by the actions of renin, angiotensin converting enzyme (ACE) and other peptidases. Ang II has a central role in cardiovascular homeostasis by regulating vasoconstriction, renal Na+ and water readsorption. In addition, Ang II induces cell growth and proliferation and has pro-inflammatory effects.
Most of the physiological actions of Ang II are mediated by AT1 a member of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. AT2 is also a GPCR, and is largely believed to have counter-regulatory roles to the ones exerted through the AT1 receptor. Hence, binding of Ang II to the AT2 receptor will result in growth arrest and apoptosis, vasodilatation and hypotension.
Angiotensin II Receptor Basic Research PackReferences
- Mukoyama, M. et al. (1993) J. Biol. Chem. 268, 24539.
- De Gasparo, M. et al. (2000) Pharmacol. Rev. 52, 415.
- Carey, R.M. and Siragy, H.M. (2003) Endocr. Rev. 24, 261.
