分子量:15.8 kDa纯度:>95% as determined by SDS-PAGE.内毒素:Less than 1.0 EU per μg of the Human VAP-B, His Tag by the LAL method.Buffer:PBS, pH7.4生物活性:产品特性:Human VAP-B, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 15.8 kDa. The predicted N-terminus is Met 1. The reducing (R) protein migrates as 16-18 kDa in SDS-PAGE .产品背景:Vesicle-associated membrane protein-associated protein B/C (VAPB) is also known as VAMP-associated protein B/C (VAMP-B/VAMP-C or VAP-B/VAP-C), which is a single-pass type IV membrane protein and belongs to the VAMP-associated protein ( VAP ) family. Involved in cellular calcium homeostasis regulation, VAPB participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity as well. VAPB can interact with VAMP1 ,VAMP2, HCV NS5A, NS5B ,ZFYVE27 (via MSP domain) and RMDN3. Human VAPB is involved in hepatitis C virus replication through interaction with NS5A and NS5B.
SDS-PAGE
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