分子量:42.9 kDa纯度:>95% as determined by SDS-PAGE.内毒素:Less than 1.0 EU per μg of the Human OX40 Ligand, Fc Tag by the LAL method.Buffer:50 mM tris, 100 mM glycine, pH7.5生物活性:Measured by its binding ability in a functional ELISA.Immobilized Human OX40, His Tag (Cat# OX0-H5224) at 2 μg/mL (100 μl/well) can bind Human OX40 Ligand, Fc Tag (Cat# OXL-H526x ) with a linear range of 1-10 ng/mL.产品特性:Human OX40 Ligand, Fc Tag is fused with a human IgG1 Fc tag at the N-terminus, and has a calculated MW of 42.9 kDa. The predicted N-terminus is Pro. The reducing (R) protein migrates as 53 kDa in SDS-PAGE due to glycosylation.产品背景:Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
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