分子量:42.9 kDa纯度:>95% as determined by SDS-PAGE.内毒素:Less than 1.0 EU per μg of the Human OX40 Ligand, Fc Tag by the LAL method.Buffer:50 mM tris, 100 mM glycine, pH7.5生物活性:Measured by its binding ability in a functional ELISA.Immobilized Human OX40, His Tag (Cat# OX0-H5224) at 2 μg/mL (100 μl/well) can bind Human OX40 Ligand, Fc Tag (Cat# OXL-H526x ) with a linear range of 1-10 ng/mL.产品特性:Human OX40 Ligand, Fc Tag is fused with a human IgG1 Fc tag at the N-terminus, and has a calculated MW of 42.9 kDa. The predicted N-terminus is Pro. The reducing (R) protein migrates as 53 kDa in SDS-PAGE due to glycosylation.产品背景:Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
SDS-PAGE
免责声明
本网页所展示的有关【Human OX40 Ligand / TNFSF4 Protein, Fc Tag】的信息/图片/参数等由的会员【
】提供，由【生物实验采购网】会员【
】自行对信息/图片/参数等的真实性、准确性和合法性负责，本平台（本网站）仅提供展示服务，请谨慎交易，因交易而产生的法
律关系及法律纠纷由您自行协商解决，本平台（本网站）对此不承担任何责任。您在本网页可以浏览【Human OX40 Ligand / TNFSF4 Protein, Fc Tag】有关的信息/图片/价格等及提供
【Human OX40 Ligand / TNFSF4 Protein, Fc Tag】的商家公司简介、联系方式等信息。
在您的合法权益受到侵害时，请您致电，我们将竭诚为您服务，感谢您对【生物实验采购网】的关注与支持！
点击图片查看原图
多肽合成，固相合成多肽
超净台/实验室设备
兔 anti HIV-1 gp24(多抗)
Biotinylated Human V
Biotinylated Human F
Biotinylated Human C
Human VAP-B Protein
Biotinylated Human F
Biotinylated Human T
Human EMMPRIN / CD14
CAR-T靶点蛋白荧光标
