分子量:48 kDa纯度:>95% as determined by SDS-PAGE.内毒素:Less than 1.0 EU per μg of the Human Ephrin-A3, Fc Tag by the LAL method.Buffer:50 mM tris, 100 mM glycine, pH7.5生物活性:产品特性:Human Ephrin-A3, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 48 kDa. The predicted N-terminus is Gln 23. The reducing (R) protein migrates as 60-65 kDa in SDS-PAGE due to glycosylation.产品背景:Ephrin-A3 (Ephrin A3) is also known as EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, EFL2, EPLG3 and LERK3,which comprises the largest subfamily of receptor protein-tyrosine kinases (RTKs), and has been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Ephrin A3 is cell surface GPI-bound ligand for Eph receptors and belongs to the family of receptor tyrosine kinases. Ephrin can bind promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.
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