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Timp1 antibody (HRP)
IPP-1
Lotus tetragonolobus lectin (LTL)翅
[VIP第1年] 指数:2
通过南京市江宁区市场监督管理局认证 
金斯瑞SurePAGE蛋白预| 货号： | A00898-40 |
| 抗体名： | 一抗 |
| 抗体英文名： | Primary Antibodies |
| 应用范围： | ELISA,Western blot |
| 宿主： | Rabbit |
| 克隆性： | 否 |
| 保存条件： | The antibody is stable for 2-3 weeks if stored at 2-8°C. For long term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. |
| 免疫原： | Synthetic phospho-peptide (KLH-coupled) corresponding to residues surrounding serine 400 of human Tau |
| 规格： | 40μg |
Tau is hyperphosphorylated by ERK, GSK-3, TPKII, and CDK5. At least thirty phosphorylation sites have been described, including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr181, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser241, Ser262, Ser285, Ser305, Ser324, Ser352, Ser356, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416, and Ser422. Specifically, TPKII phosphorylates serines 202 and 404. GSK-3β transfection phosphorylates serines 199, 202, 235, 396, 404, and 413, and threonines 205 and 231. These sites are among the major abnormal phosphorylation sites of Tau. Phosphorylation on these sites reduces the ability of a given Tau species to promote microtubule self-assembly. Hyperphosphorylated Tau is the major protein of the paired helical filaments (PHFs), which make up the pathological neurofibrillary tangles of Alzheimer’s disease (AD). The PHFs are also found in the lesions of other central nervous system disorders.
GenScript Rabbit Anti-Tau (Phospho-Ser400) Polyclonal Antibody is developed in rabbit using a synthetic phospho-peptide (KLH-coupled) corresponding to residues surrounding serine 400 of human Tau.
温馨提示：不可用于临床治疗。
