货号: | IVL-0037-AP |
抗体名: | Mouse anti-human BNP |
抗体英文名: | Alkaline Phosphatase BNP antibody conjugate (50E1) |
靶点: | BNP |
浓度: | 0.1mg/ml |
应用范围: | E, WB |
宿主: | Mouse |
适应物种: | human |
标记物: | Alkaline Phosphatase |
克隆性: | 否 |
保存条件: | 4度 |
形态: | 请参考说明书 |
亚型: | IgG1 |
免疫原: | BNP |
规格: | 0.1mg |
Brain natriuretic peptide (BNP) is a cardiac hormone that belongs to the family of structurally related proteins referred to as the natriuretic peptide family. BNP is synthesized in cardiac myocytes as preproBNP, a prepropeptide. The molecule is then processed by proteolytic cleavage to produce pro-BNP. Pro-BNP is further cleaved to produce biologically active BNP and N-Terminal-proBNP (NT-proBNP) peptides, which are released into the bloodstream. In addition, O-glycosylated forms of pro-BNP have also been reported in human plasma. BNP production is regulated at the transcriptional level and functions to regulate blood pressure by vasodilation, natriuresis and diauresis. Elevated plasma levels of both BNP and NT-proBNP have been reported in a variety of cardiac pathologies including heart failure (HF), cardiomyopathy and cardiac amyloidosis. As a result, BNP and related peptides, including proBNP and NT-proBNP, have become widely recognised biomarkers for heart failure and for monitoring disease severity in patients with heart failure and other cardiac pathologies.
温馨提示:不可用于临床治疗。
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