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SCILOGEX赛洛捷克 MS-| 货号： | IWN1016-0001MG |
| 保存条件： | -20℃ |
| CAS号： | 264218-23-7 |
| 供应商： | 上海伟进生物科技有限公司 |
| 数量： | 50 |
| 英文名： | SB 415286 |
| 保质期： | 2 years |
| 规格： | 1mg |
Biological Activity
The anilinomaleimide SB 415286 is a potent, ATP-competitive and highly selective inhibitor of GSK-3α (IC50= 78 nM, Ki= 31 nM), displaying similar potency against GSK-3β. SB 415286 (10 µM) exhibits little or no inhibition of the other 24 members of the kinase selectivity panel. This compound stimulates glycogen synthesis in human liver cell line (EC50= 2.9 μM) and induces transcription of a β-catenin-LEF/TCF regulated reporter gene in HEK293 cells [1]. SB 415286 prevents both central and peripheral nervous system neurones from death by reduced PI 3-kinase pathway activity [2]. SB 415286 exerts a cytoprotective effect against H2O2damage in rat B65 cell lines as well as in cerebellar granule cells (CGN), this effect may be explained by its antioxidant properties[3].
Chemical Properties
| Cas No.: 264218-23-7 | M. Wt.: 359.73 |
| Formula: C16H10ClN3O5 | Purity: ≥98% |
| Synonym: SB415286, SB-415286 | |
| Chemical Name: 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione | |
| Appearance: Yellow powder | |
| Solubility: Soluble in DMSO (16 mg/mL), very sparingly soluble in water. | |
| Storage: Store powder at -20 ºC for the stability of two years, protect from light. | |
Application Concentration (Just for reference)
The appropriate working concentration of SB 415286 depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use.
