科学大讲堂 | 信号通路专题系列三： Wnt信号通路_产品说明_仪器仪表技术文献
提供者：34025060 发布时间：2018/12/11 阅读次数：55次
Wnt proteins are a family of secreted glycolipids involved in the regulation of embryogenesis ａnd tissue homeostasis. The Wnt pathways are fundamental in cell proliferation, cell polarity ａnd cell fate determination. Misregulation of these signaling pathways has been linked to several human pathologies such as cancer, diabetes ａnd some inherited diseases. Wnt蛋白是参与调控胚胎发生和组织稳态的分泌糖脂家族。 Wnt通路是细胞增殖，细胞极性和细胞命运决定的基础。 这些信号传导途径的失调与几种人类疾病如癌症，糖尿病和一些遗传疾病有关。
There are three well-studied Wnt signaling pathways. The most established pathway, Wnt/beta-catenin, is highly conserved throughout metazoans ａnd serves as a stem cell niche signal. This pathway retains an inactivated or activated state, ａnd as such regulates the amount of transcriptional co-activator beta-catenin. In the absence of Wnt, cytoplasmic beta-catenin protein is constantly degraded by the action of ‘destruction complex”. In the activated state, Wnt binds to a receptor complex containing Frizzled (Fzd) ａnd low-density lipoprotein receptor-related protein 5/6 (LRP5/6), the destruction complex is inactivated allowing the stabilization ａnd nuclear import of beta-catenin. 有三个经过深入研究的Wnt信号通路。最常建立的途径Wnt /β-连环蛋白在整个后生动物中高度保守，并充当干细胞生态位信号。该途径保持失活或活化状态，并且因此调节转录共激活剂β-连环蛋白的量。在缺乏Wnt的情况下，细胞质β-连环蛋白通过“破坏复合体”的作用不断降解。 在激活状态下，Wnt与包含卷曲蛋白（Fzd）和低密度脂蛋白受体相关蛋白5/6（LRP5 / 6）的受体复合物结合，破坏复合物被灭活，从而允许β-连环蛋白的稳定化和核输入。 The other two pathways are the Planar pathway ａnd the Wnt/calcium pathway. Both function independently of beta-catenin. Wnt also regulates a number of other signaling pathways still being actively researched. 另外两条途径是Planar途径和Wnt /钙途径。两者都独立于β-连环蛋白。Wnt还参与调节一些仍在积极研究的其他信号通路。Helping your research Biorbyt has an extensive range of small molecules ａnd antibodies available as research reagents to target proteins in the Wnt pathways. We provide the best service ａnd a simple buying process allowing you to focus on your valuable research. Take a look at our product pages where you will find competitive pricing, lead times, ａnd easy delivery options. If you have any questions, just ask us. Biorbyt有广泛的小分子和抗体可用作研究试剂以靶向Wnt途径中的蛋白质。我们提供最好的服务和简单的购买流程，让您专注于您的宝贵研究。请查阅我们的产品页面，您可以找到具有竞争力的价格，交货期和易于交付的选项。如果您有任何问题，请随时联系我们。Wnt 信号通路精品抗体
